† highlights; * equal contribution; Google Scholar.
Preprints & Manuscripts in Review
Robust trigger wave speed in Xenopus cytoplasmic extracts
J.-H. Huang*, Yuping Chen, W. Y. C. Huang, Saman Tabatabaee, and J. E. Ferrell
bioRxiv 2023 [Preprint] (submitted for peer review)
Research Articles
17. † Membrane localization accelerates association under conditions relevant to cellular signaling
W. Y. C. Huang#, Steven G. Boxer, and J. E. Ferrell# (# corr authors)
PNAS 2024,121:e2319491121. [Journal]
16. Measuring Molecular Diffusion in Self-Organizing Xenopus Extracts by Fluorescence Correlation Spectroscopy
W. Y. C. Huang, J. E. Ferrell, and Xianrui Cheng
Cell Cycle Control. Methods in Molecular Biology 2024, 2740:107-115. [Book Series]
–Before 2024–
15. Cytoplasmic organization promotes protein diffusion in Xenopus extracts
W. Y. C. Huang, X. Cheng, and J. E. Ferrell
Nature Communications 2022, 13:5599. [Journal]
See also: Faculty Opinions. [Site]
14. Stochasticity and positive feedback enable enzyme kinetics at the membrane to sense reaction size
A. A. Lee, W. Y. C. Huang, S. D. Hansen, N. H. Kim, S. Alvarez, and J. T. Groves
PNAS 2021, 118:e2103626118. [Journal]
13. Relating cellular signaling timescales to single-molecule kinetics: a first-passage time analysis of Ras activation by SOS
W. Y. C. Huang, S. Alvarez, Y. Kondo, J. Kuriyan, and J. T. Groves
PNAS 2021, 118:e2103598118. [Journal]
12. Coupled membrane lipid miscibility and phosphotyrosine-driven protein condensation phase transitions
J. K. Chung*, W. Y. C. Huang*, C. Carbone, A. N. Parikh, R. D. Vale, and J. T. Groves
Biophysical Journal 2021, 120:1257-1265. [Journal]
11. Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction
S. D. Hansen, W. Y. C. Huang, Y. K. Lee, P. Bieling, S. M. Christensen, and J. T. Groves
PNAS 2019, 116:15013-15022. [Journal]
10.† A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS
W. Y. C. Huang, S. Alvarez*, Y. Kondo*, Y. K. Lee, J. K. Chung, H. Y. M. Lam, K. H. Biswas, J. Kuriyan, and J. T. Groves
Science 2019, 363:1098-1103. [Journal]
See also: Perspective: Dwelling at membranes promotes decisive signaling. Science 2019, 363:1036-1037. [Journal]
#######Research Highlight, Nature Reviews Molecular Cell Biology 2019, 20:263. [Journal]
#######LBNL News Center, April 1, 2019. [News]
#######Faculty of 1000. [Site]
9. Allosteric modulation of Grb2 recruitment to the intrinsically disordered scaffold protein, LAT, by remote site phosphorylation
W. Y. C. Huang*, J. Ditlev*, H.-K. Chiang, M. K. Rosen, and J. T. Groves
Journal of the American Chemical Society 2017, 139:18009-18015. [Journal]
8. Dynamic scaling analysis of molecular motion within the LAT:Grb2:SOS protein network on membranes
W. Y. C. Huang, H.-K. Chiang, and J. T. Groves
Biophysical Journal 2017, 113:1807-1813. [Journal]
7. Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate co-translational protein targeting
Y.-H. Hwang Fu, W. Y. C. Huang, K. Shen, J. T. Groves, T. Millers, and S. Shan
eLife 2017, 6:e25885. [Journal]
6. † Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS
W. Y. C. Huang, Q. Yan, W.-C. Lin, J. K. Chung, S. D. Hansen, S. M. Christensen, H.-L. Tu, J. Kuriyan, and J. T. Groves
PNAS 2016, 113:8218-8223. [Journal]
5. E-cadherin junction formation involves an active kinetic nucleation process
H. Biswas*, K. L. Hartman*, C.-H. Yu, O. J. Harrison, H. Song, A. W. Smith, W. Y. C. Huang, W.-C. Lin, Z. Guo, A. Padmanabhan, S. M. Troyanovsky, M. L. Dustin, L. Shapiro, B. Honig, R. Zaidel-Bar, and J. T. Groves
PNAS 2015, 112:10932-10937. [Journal]
4. Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner
R. Lowe*, J. H. Tang*, J. Yassif, M. Graf, W. Y. C. Huang, J. T. Groves, K. Weis, and J. T. Liphardt
eLife 2015, 4:e04052. [Journal]
3. H-Ras forms dimers on membrane surfaces via a protein-protein interface
W.-C. Lin*, L. Iversen*, H.-L. Tu, C. Rhodes, S. M. Christensen, J. S. Iwig, S. D. Hansen, W. Y. C. Huang, and J. T. Groves
PNAS 2014, 111:2996-3001. [Journal]
2. Depletion of water molecules near the end stage of steric zipper formation
H.-M. Cheng, W. Y. C. Huang, T. W. T. Tsai, Y. Mou, and J. C. C. Chan
Journal of the Chinese Chemical Society 2013, 60:784-800. [Journal]
1. Steric zipper formed by hydrophobic peptide fragment of Syrian hamster prion protein
H.-M. Cheng, T. W. T. Tsai, W. Y. C. Huang, H.-K. Lee, H.-Y. Lian, F.-C. Chou, Y. Mou, and J. C. C. Chan.
Biochemistry 2011, 50:6815−6823. [Journal]
Conference Proceedings
1. Proceedings of the 5th international RASopathies symposium: when development and cancer intersect
K. A. Rauen, L. Schoyer, L. Schill, B. Stronach, J. Albeck, B. S. Andresen, H. Cavé, M. Ellis, S. M. Fruchtman, B. Gelb, C. Gibson, K. Gripp, E. Hefner, W. Y. C. Huang, M. Itkin, B. Kerr, C. Linardic, M. McMahon, B. Oberlander, E. Perlstein, N. Ratner, L. Rogers, A. Schenck, S. Shankar, S. Shvartsman, D. Stevenson, E. Stites, P. Stork, C. Sun, M. Therrien, E. Ullian, B. Widemann, E. Yeh, G. Zampino, M. Zenker, W. Timmer, and F. McCormick
American Journal of Medical Genetics Part A 2018, 176:2924-2929. [Journal]